Table 2. Hematological data of Sprague-Dawley (SD) rats orally administered fdLM for 28 days
| Parameters | fdLM (mg/kg/day) |
| 0 mg/kg/day | 750 mg/kg/day | 1,500 mg/kg/day | 3,000 mg/kg/day |
| Males | | | | |
| WBC (K/μL) | 6.64±1.36 | 9.67±1.67 | 7.82±1.94 | 7.77±2.53 |
| NE (K/μL) | 0.92±0.49 | 0.9±0.44 | 0.86±0.29 | 0.94±0.45 |
| EO (K/μL) | 0.06±0.02 | 0.08±0.02 | 0.08±0.03 | 0.07±0.04 |
| BA (K/μL) | 0±0 | 0±0 | 0±0.01 | 0±0 |
| LY(K/μL) | 5.49±1.31 | 8.42±1.51 | 6.67±1.62 | 6.52±2.01 |
| MO (K/μL) | 0.15±0.07 | 0.21±0.09 | 0.16±0.05 | 0.2±0.13 |
| LUC (K/μL) | 0.02±0.01 | 0.06±0.03 | 0.05±0.05 | 0.04±0.03 |
| NEP (%) | 13.9±6.2 | 9.3±4.1 | 10.8±1.8 | 11.9±2.8 |
| EOP (%) | 1±0.3 | 0.8±0.3 | 1.1±0.4 | 0.9±0.4 |
| BAP (%) | 0±0 | 0±0 | 0.1*±0 | 0±0 |
| LYP (%) | 82.5±6.4 | 87.1±4.4 | 85.4±2.4 | 84.4±3.3 |
| MOP (%) | 2.3±1.3 | 2.1±0.7 | 2.1±0.7 | 2.3±0.9 |
| LUP (%) | 0.3±0.2 | 0.6±0.3 | 0.6±0.5 | 0.5±0.2 |
| RBC (M/μL) | 7.83±0.21 | 7.37±0.7 | 7.54±0.4 | 7.56±0.38 |
| Hb (g/dL) | 16±0.5 | 15.4±0.5 | 15.6±0.8 | 15.4±0.5 |
| RDW (%) | 10.8±0.2 | 11.4±0.3 | 11.3±0.6 | 11.2±0.4 |
| HCT (%) | 45.6±1.7 | 42.8±3.5 | 44.4±2.2 | 43.6±1.6 |
| MCV (fL) | 58.2±1.7 | 58.1±1.9 | 58.8±0.9 | 57.7±2.1 |
| MCH (pg) | 20.4±0.5 | 21.1±2 | 20.7±0.7 | 20.4±1 |
| MCHC (g/dL) | 35±0.1 | 36.2±3.1 | 35.2±0.7 | 35.4±0.4 |
| Reti (%) | 3±0.22 | 3.22±0.38 | 3.23±0.45 | 3.17±0.39 |
| PLT (K/μL) | 1,216±120 | 1,228±93 | 1,134±114 | 1,150±112 |
| MPV (fL) | 7.7±0.2 | 8±0.3 | 8±0.2 | 7.8±0.3 |
| Females | | | | |
| WBC (K/μL) | 5.09±2.04 | 5.57±1.56 | 6.27±0.81 | 5.55±2.47 |
| NE (K/μL) | 0.62±0.42 | 0.64±0.18 | 0.52±0.21 | 0.59±0.3 |
| EO (K/μL) | 0.06±0.02 | 0.07±0.04 | 0.09±0.02 | 0.07±0.03 |
| BA (K/μL) | 0±0 | 0±0 | 0±0 | 0±0 |
| LY (K/μL) | 4.29±1.58 | 4.68±1.42 | 5.53±0.73 | 4.73±2.27 |
| MO (K/μL) | 0.09±0.07 | 0.14±0.03 | 0.09±0.04 | 0.1±0.08 |
| LUC (K/μL) | 0.03±0.01 | 0.04±0.02 | 0.04±0.02 | 0.04±0.02 |
| NEP (%) | 11.4±4.2 | 11.8±2.7 | 8.2±3 | 11.7±5.5 |
| EOP (%) | 1.2±0.5 | 1.3±0.5 | 1.5±0.5 | 1.5±0.5 |
| BAP (%) | 0.1±0.1 | 0±0 | 0±0 | 0.1±0.1 |
| LYP (%) | 85.1±4.6 | 83.6±3.4 | 88.2±3.3 | 84.5±5.7 |
| MOP (%) | 1.7±0.6 | 2.5*±0.5 | 1.4±0.5 | 1.7±0.6 |
| LUP (%) | 0.5±0.2 | 0.8±0.4 | 0.6±0.2 | 0.6±0.2 |
| RBC (M/μL) | 7.37±0.23 | 7.71±0.43 | 7.59±0.24 | 7.44±0.19 |
| Hb (g/dL) | 15.3±0.2 | 15.6±0.5 | 15.6±0.5 | 15.2±0.6 |
| RDW (%) | 10.4±0.4 | 10±0.2 | 10.2±0.1 | 10.1±0.3 |
| HCT (%) | 42.5±0.6 | 43.5±1.4 | 43.3±1.4 | 42.6±1.6 |
| MCV (fL) | 57.7±1.3 | 56.5±2.4 | 57.1±2.4 | 57.3±1.3 |
| MCH (pg) | 20.7±0.5 | 20.3±0.8 | 20.5±0.9 | 20.5±0.5 |
| MCHC (g/dL) | 35.9±0.5 | 36±0.1 | 36±0.4 | 35.7±0.1 |
| Reti (%) | 2.63±0.33 | 2.02±0.49 | 2.21±0.45 | 2.48±0.42 |
| PLT (K/μL) | 1,134±116 | 1,116±128 | 1,243±164 | 969±271 |
| MPV (fL) | 7.8±0.2 | 7.4±0.2 | 7.6±0.2 | 7.6±0.4 |
Each value represents the mean±SD (n=5).
Significant difference at p<0.05 levels compared to the vehicle control.
fdLM, freeze-dried powder of Locusta migratoria; WBC, white blood cell; NE, neutrophil; EO, eosinophil; BA, basophil; LY, lymphocyte; MO, monocyte; LUC, large unstained cell; NEP, percent of neutrophil; EOP, percent of eosinophil; LYP, percent of lymphocyte; MOP, percent of monocyte; LUP, percent of large unstained cell; RBC, red blood cell; HB, hemoglobin; RDW, red cell distribution width; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; Reti, reticulocyte; PLT, platelet; MPV, mean platelet volume.