| Bovine milk-derived EVs are uptaken into the intestinal cell model (Caco-2) and have more beneficial features than liposomes. | (Roerig et al., 2021) |
| EVs-encapsulated miRNA was stable in both in vitro and in vivo digestion, and it was confirmed that cellular uptake was possible and reached each organ upon oral administration to mice. | (López de Las Hazas et al., 2022) |
| The drug-loaded bovine milk exosomes showed higher efficiency and targetability compared to the free drug in both cell and mouse tests. | (Munagala et al., 2016) |
| Fluorophore-labeled bovine milk exosomes and miRNAs are uptaken by human colon carcinoma cells and rat small intestinal cells, which are mediated by endocytosis. | (Wolf et al., 2015) |
| Milk exosomes crossed intestinal epithelial cells in in vitro culture, and milk exosomal miRNAs can resist in vitro digestion and cross the intestinal barrier. | (Rani et al., 2017) |
| When fluorophore-labeled bovine milk exosomes and miRNA were orally administered, it was expressed in the organs of mice and pigs, confirming that interspecies transfer was possible. | (Manca et al., 2018) |
| Postprandial blood analysis of newborn calves showed that bovine colostrum-derived EVs were transferred into the circulation but not miRNAs. | (Kirchner et al., 2020) |
| Confirmation of uptake of bovine milk EVs into intestinal epithelial cells through fluorophore-conjugated lactadherin labeling. | (Hansen et al., 2020) |
| Confirmation of bovine milk exosome uptake into differentiated THP-1 cells by flow cytometry and fluorescence microscopy. | (Izumi et al., 2015) |
| Confirmation of uptake of PKH-labeled bovine colostrum-derived EVs into RAW 264.7 cells | (Maburutse et al., 2017) |
| Resistance of miRNA and mRNA in milk with acidic conditions and RNase treatment. | (Izumi et al., 2012) |
| Bovine milk exosomal long noncoding RNAs are protected from degradation during in vitro digestion system. | (Zeng et al., 2019) |
| Bovine milk exosomal small interfering RNA resists in vitro digestive conditions and is uptaken into Caco-2 cells. | (Shandilya et al., 2017) |
| bta-miR-223 and bta-miR-125b present in commercial cow milk are resistant in a computer-controlled gastrointestinal model (TIM-1). | (Benmoussa et al., 2016) |
| The integrity and molecular structure of EVs in bovine milk are affected by Industrial processing. | (Kleinjan et al., 2021) |
| Processing in commercial dairy plants have no statistical effect on the abundance value of miRNAs in dairy products. | (Shome et al., 2021) |